Dr. Mehellou has kindly shared an article on his work with us, which he has called Sneaking phosphorylated molecules into cells: a powerful strategy in drug discovery and biotechnology.
“Phosphorylated synthetic molecules and biomolecules play an important role in health and disease. They have shown great potential as therapeutics and useful biotechnological tools. However, the polar nature of phosphate groups, which limits their (passive) cellular uptake has hindered their use. To address this shortage, a number of phophate prodrugs have been developed. Continue reading